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Various types of blood enhancing medication and side effects

Iron is one of the important minerals needed by the body. Many people who take blood-boosting drugs to overcome anemia, a condition of lack of blood caused by lack of this mineral. But watch out. Even though it is classified as a supplement, blood-boosting drugs must be taken according to the proper rules and dosages. Moreover, don't carelessly take this supplement if you don't really need it.

A study found that iron levels in this supplement may be too high and can be dangerous. The effect is reported to damage the body in just 10 minutes.

Blood enhancing drugs are intended to overcome blood deficiency, such as anemia and neutropenia. Anemia occurs when the blood does not have enough red blood cells or hemoglobin, which is the main part of red blood cells that binds oxygen. As a result, cells in the body will not get enough oxygen.

Whereas neutropenia is a condition in which the neutrophil white blood cell count in the body is low or below normal. Neutrophils play a role in fighting infections, especially those caused by bacteria and fungi.

How many daily iron requirements are recommended?

Everyone's need for iron varies depending on the level of activity, age and sex.

The number of daily iron requirements based on the recommendation of the Daily Nutrition Adequacy Rate set by the Ministry of Health for men generally ranges from 13-19 mg / day, while for women is 26 mg per day.

Women need more iron to stay healthy than men. Women need more iron because of menstrual blood loss. Pregnant women may also need iron supplements to make sure they get enough nutrients to grow their babies in the womb.




But this does not mean you can just take blood-boosting medication to meet your daily iron needs. Just like other drugs, arbitrarily measuring the dosage of this drug without the doctor's knowledge will cause various risks of side effects that harm the body.

Blood Enhancing Medication for Anemia

  • Iron, vitamin B12 and folate

To produce red blood cells, the body needs nutrients, iron, vitamin B12 and folate. When these three substances are not fulfilled from daily nutrition, the body can experience anemia. If it is caused by iron deficiency anemia, the body will need to take additional iron supplements to meet the body's iron needs so that the process of forming red blood cells can run normally. Whereas if there is vitamin B12 and folate deficiency anemia, the body will need supplements of vitamin B12 and folic acid.

Some side effects of iron that can occur are digestive problems such as abdominal pain, nausea, diarrhea, and constipation, black bowel movements, and decreased appetite. While the side effects of vitamin B12 and folic acid supplements that can occur are dizziness, headaches, and nausea. But the side effects of these two supplements generally occur when taken in high doses.

  • Recombinant human erythropoietin

The growth of red blood cells in the blood is regulated by the hormone erythropoietin (EPO) produced in the kidneys. When this hormone cannot be produced due to certain diseases, the body will experience anemia. This drug is used for the treatment of chronic anemia caused by interference with EPO hormones in children and adults. In addition, it can also be used in patients with chronic renal failure, cancer patients undergoing chemotherapy, patients with HIV, and patients who need long-term blood transfusion.

Giving this drug can not be given to patients with uncontrolled high blood pressure, allergies to animal protein products or human albumin, seizures, epilepsy, chronic liver failure, have red blood cell abnormalities such as humans, seizures, epilepsy, chronic liver failure, have red blood cell disorders such as sickle cell anemia, cancer, and pregnant and lactating women. This blood booster drug has side effects such as headaches, allergic reactions, joint pain, nausea, swelling, fatigue, fever, and increased blood pressure.

Blood Enhancing Medication for Neutropenia

  • Recombinant human granulocyte colony stimulating factor

The growth of white blood cells including neutrophils in the body occurs in the bone marrow and is controlled by a substance called Granulocyte Colony Stimulating Factor (G-CSF). If there is a medical illness or disorder that blocks the work of G-CSF, the body will experience neutrophil cell deficiency or neutropenia. There are three types of drugs that function as synthetic G-CSF, namely lenograstim, filgrastim, and pelfigrastim.

These drugs are used to treat neutropenia in a number of conditions, such as post chemotherapy, neutropenia due to impaired growth of white blood cells, and bone marrow transplant surgery.

This drug cannot be given to patients with allergies to synthetic G-CSF drugs, impaired kidney and liver function or in patients with leukemia who have not undergone chemotherapy treatment. While side effects include bone pain, headache, weakness, abdominal pain, swollen spleen, and increased platelets.

  • Stem cell therapy (stem cell therapy)

Stem cell therapy is a treatment method for treating disorders of blood cell growth in the bone marrow. This therapy is now used as a blood booster for diseases such as white and red blood cell growth disorders or aplastic anemia, autoimmune diseases and cancer. But this therapy can cause a number of side effects, there is pain, rejection reaction to donor cells, infection, and organ damage.

Blood enhancing drugs can damage the body's DNA

Research conducted by Claire Shovlin from the National Heart and Lung Institute at Imperial College London found that blood enhancing drugs consumed by millions of people without a doctor's prescription can damage the body in just 10 minutes.

Dr. Shovlin and his team tested the high-dose effect of these minerals on human endothelial cells, which connect arteries and veins. Ten minutes after they injected a high dose of blood enhancing drugs in cell culture samples, found signs of DNA damage in the walls of the blood vessels. Endothelial cells appear quite sensitive to excessive amounts of iron and can trigger cell damage in just 10 minutes after the drug is taken.

Every cell in the body has an automatic program to repair itself. But Shovlin explained that when we add iron, this program is forced to work harder than usual. It is not known exactly what the embodiment of DNA damage in the blood vessel wall due to overdose of iron intake. Further research is needed on the impact of cell damage to a greater extent.

However, some people who take iron supplements for haemorrhagic telangiectasia condition, a congenital abnormality of the blood vessels reported experiencing more frequent nasal bleeding after taking the drug.

If you suffer from anemia or neutropenia, it is recommended to always consult a doctor so that the drug is given according to the cause.





References

References

Ria, et al. Filgrastim, lenograstim and pegfilgrastim in the mobilization of peripheral blood progenitor cells in patients with lymphoproliferative malignancies. Clinical and Experimental Medicine. 2015. 15, pp. 145-150. Cancer Research UK (2018). Granulocyte colony stimulating factor (G-CSF). Drugs. Drugs A to Z. Ferrous sulfate Side Effects.

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Is a health and wellness enthusiast. In him free time, she loves to travel and taste different types of teas.

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